Under compressive strains of 15%, lateral stresses vary by as much as 212% (from 2.7 to ?3.0 MPa), which would result in significant variation in
The PKC family includes at least ten serine/threonine kinases playing a central role in cell proliferation, differentiation, death31 and survival,32. A constitutive-phosphorylated ARF mutant over
We identify these cells as Treg and Th, respectively. Open in a separate window Figure 1 Computational model of T cell differentiation: (A) Signaling network
Variations considered significant at *p< 0.05, **p < 0.01, and ***p < 0.001 respect to control, and # p< 0.05, ## p < 0.01, and
These findings suggest that for a vertical combination to be synthetic lethal, each inhibitor must target a distinct node of the RAF-MEK-ERK pathway (Figure S2E).
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