Laboratory data suggest that platelets remain functional for 14C21 days without the need for agitation.72, 73, 74, 75, 76 Consider frozen platelets for bleeding patients only 77, 78 Plasma Remove requirements to freeze plasma Consider use of liquid (never frozen) plasma if freezer capacity or staff to freeze plasma are in short supply.79 Whole Blood Use of whole blood Consider if staff to manufacture components are in short supply or for massive transfusion.80, 81, 82, 83, 84 A first step is to review steps to minimise wastage. with COVID-19 are estimated to pass away.1 Transfusion professionals are responding to uncertain patterns of demand for blood components, to reductions in the numbers of donations, and to loss of crucial staff because of Hoechst 33258 analog 2 sickness. A key activity for transfusion institutions during this period, whether hospital-based or individual blood transfusion services, is the monitoring of supply and demand so that sufficient blood stocks are managed to support ongoing crucial requires, for example, major trauma. The objective of this Review is usually to provide a synthesis of the evolving published literature on COVID-19 and to provide expert opinion relevant to transfusion practice in occasions of potential or Rabbit Polyclonal to ACTN1 actual shortage, addressing the entire transfusion chain from donor to individual. The search strategy that underpinned this Review has been regularly updated to incorporate new, relevant information. The focus is usually on providing practical guidance to support transfusion specialists worldwide at different stages in the pandemic, including as health services reopen for all those activities. Further updates of searching will ensure that any new information is usually highlighted for readers. Method A systematic approach was taken to search and identify all published literature relevant to COVID-19. Searches were done using a comprehensive search strategy (appendix p 1). These searches were not limited by language or study type and were run daily by an information specialist. The following databases were searched: WHO COVID-19 global research database,2 PubMed, and Vox Sanguinis International Society for Blood Transfusion Science Series. In addition, a search was carried out for relevant general articles on blood and shortage, blood and contingency planning, and blood and major incident planning (appendix pp 1C2). All recognized references were screened by one person using predefined eligibility criteria (appendix pp 2C3). Each eligible research was tagged with clinical key words, ranging in themed areas Hoechst 33258 analog 2 from donor to recipient. Any type of study or evaluate was considered relevant. Outputs of searches were examined and incorporated by groups of clinicians into five important section themes defined at the onset of the project and explained in the following sections of this Review. A table of registered, randomised controlled trials was created by weekly searches of ongoing trial registries, ClinicalTrials.gov, and the COVID-19 subset of the Who also International Clinical Trials Registry Platform database.3 Results From March 23 to April 30, 2020, systematic searches identified over 9000 citations. Hoechst 33258 analog 2 During April, 2020, 7715 citations were screened for eligibility and 414 were included in the final citation list. Physique 1 shows the steady increase in citations during April and the proportion of citations relevant to the topic of transfusion chain from donor to recipient. The search narrative for emergency planning retrieved 1255 recommendations after duplicates and irrelevant references were removed, from which 121 citations were included. A few ongoing systematic reviews were also recognized.4 Open in a separate window Determine 1 The total quantity of COVID-19-related citations and the proportion of those relevant to transfusion Theme 1: features of SARS-CoV-2 contamination that affect patients’ needs for transfusion Characteristics of SARS-CoV-2 contamination have been explained by multiple reports.5, 6 Understanding these features informs the approaches required to address potential mismatches between blood supply (theme 2) and demand, including the activities of patient blood management implementation (theme 4). Anaemia is usually.